hossein ghadampour-vahed; Ali Kazemi; bagher minaei; zabih allah ghadampour-vahed
Volume 12, Issue 2 , September 2019, , Pages 71-78
Abstract
The purpose of this study was to investigate the effect of six weeks of HIIT under simulated microgravity condition on morphological changes of radial nerve myelin sheath in male rats. In present study, 24 male wistar rats were randomly selected and divided into four groups including: TS(training during ...
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The purpose of this study was to investigate the effect of six weeks of HIIT under simulated microgravity condition on morphological changes of radial nerve myelin sheath in male rats. In present study, 24 male wistar rats were randomly selected and divided into four groups including: TS(training during suspension:n=6), CS(suspension:n=6), T(training:n=6), C(control:n=6). The training groups run on treadmill for six weeks (five days in week). 24 hours after the last training session, the animals were prepared for tissue samples. At the end of the experiment, changes in myelin sheath were measured by Luxol fast blue. Our results showed that the percentage of changes in myelin sheath in HIIT group under simulate microgravity (p≤0.001) was highest than other groups, significantly (30/27+5/27). Based on the results, HIIT under simulated microgravity condition affected on changes in myelin sheath, Therefore, it seems that can play an effective role in improvement of the clinical status of neurological patients and decrease side effects in Astronauts.
Vahid Nikbakht; Ali Kazemi; Zahra Hajebrahimi; Neda Khaledi; Mohammad Asadi golzar
Volume 9, Issue 4 , April 2017, , Pages 63-68
Abstract
Endothelial cells differently respond to microgravity condition. The evolution of these responses leads to a more clear understanding of cardiovascular diseases in both gravity and micro-gravity conditions. The aim of this study was to investigate the effects of microgravity condition on serum levels ...
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Endothelial cells differently respond to microgravity condition. The evolution of these responses leads to a more clear understanding of cardiovascular diseases in both gravity and micro-gravity conditions. The aim of this study was to investigate the effects of microgravity condition on serum levels of vascular endothelial growth factor as a motivator for angiogenesis and vasculogenesis processes. A total of 20 rats were randomly divided into two groups including control group and suspension group. The results showed that the VEGF levels of suspension group were higher than control group but it was not significant (P> 0.05). It seems that the hindlimb suspension model used for stimulating microgravity condition does not affect the VEGF in serum levels in male Wistar rats. This may be the result of the body's adaptive response after six weeks. Another probable reason is that VEGF does not play an effective role in cardiovascular changes in microgravity condition. Also the influences of other factor may affect the results.
